|
|
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
BMK
|
| |
BRENDA:
BR29297;
BR50597;
BS188050;
BS451044
KEGG:
R02082
MetaCyc:
1.1.1.34-RXN
SABIO-RK:
2092
|
|
|
|
(R)-mevalonate + NAD+ + CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
BMK
|
| |
BRENDA:
BR29347;
BR50597-a;
BS188686
KEGG:
R02081
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN
SABIO-RK:
6923
|
|
|
|
(R)-mevalonate + ATP <=> H+ + (R)-5-phosphomevalonate + ADP
|
2.7.1.36
mevalonate kinase
|
–
|
BMK
|
| |
BRENDA:
BR47775
KEGG:
R02245
MetaCyc:
MEVALONATE-KINASE-RXN
SABIO-RK:
2215
|
|
|
|
(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H+
|
2.7.1.185
mevalonate 3-kinase
|
–
|
BMK
|
| |
BRENDA:
BR51126
KEGG:
R10779
MetaCyc:
RXN-15647
|
|
|
|
(R)-mevalonate + NAD+ <=> DL-mevaldate + NADH + H+
|
1.1.1.32
mevaldate reductase
1.1.1.88
hydroxymethylglutaryl-CoA reductase
|
–
–
|
|
| |
BRENDA:
BR29295
KEGG:
R02246
SABIO-RK:
11524;
2216
|
|
|
|
(R)-mevalonate + NADP+ <=> DL-mevaldate + NADPH + H+
|
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.32
mevaldate reductase
1.1.1.33
mevaldate reductase (NADPH)
|
–
–
–
|
|
| |
BRENDA:
BR29296
KEGG:
R02247
SABIO-RK:
2217
|
|
|
|
(R)-mevalonate + NADP+ <=> (R)-mevaldate + NADPH + H+
|
1.1.1.33
mevaldate reductase (NADPH)
|
–
|
|
| |
MetaCyc:
MEVALDATE-REDUCTASE-NADPH-RXN
|
|
|
|
(R)-mevalonate + NAD+ <=> (R)-mevaldate + NADH + H+
|
1.1.1.32
mevaldate reductase
|
–
|
|
| |
MetaCyc:
MEVALDATE-REDUCTASE-RXN
|
|
|
|
ITP + (R)-mevalonate <=> IDP + (R)-5-phosphomevalonate
|
2.7.1.36
mevalonate kinase
|
–
|
|
| |
BRENDA:
BS379963
|
|
|
|
dTTP + (R)-mevalonate <=> dTDP + (R)-5-phosphomevalonate
|
2.7.1.36
mevalonate kinase
|
–
|
|
| |
BRENDA:
BS380365
|
|
|
|
GTP + (R)-mevalonate <=> GDP + (R)-5-phosphomevalonate
|
2.7.1.36
mevalonate kinase
|
–
|
|
| |
BRENDA:
BS379813
|
|
|
|
CTP + (R)-mevalonate <=> CDP + (R)-5-phosphomevalonate
|
2.7.1.36
mevalonate kinase
|
–
|
|
| |
BRENDA:
BS379611
|
|
|
|
mevaldyl-CoA + NADPH + H+ + H2O <=> (R)-mevalonate + CoA + NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
| |
BRENDA:
BS371044
|
|
|
|
(R)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ <=> (R)-mevalonate + CoA + 2 NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
| |
BRENDA:
BS394812
|
|
|
|
(R)-mevaldehyde + NADPH + H+ <=> (R)-mevalonate + NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
| |
BRENDA:
BS427793
|
|
|
|
mevaldehyde + NADPH <=> (R)-mevalonate + NADP+
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
|
–
|
|
| |
BRENDA:
BS373848
|
|
|
|
UTP + (R)-mevalonate <=> UDP + (R)-5-phosphomevalonate
|
2.7.1.36
mevalonate kinase
|
–
|
|
| |
BRENDA:
BS380402
|
|
